抗生素抗药性:全球卫生危机的日益严峻挑战

抗生素抗药性已成为21世纪最严峻的公共卫生挑战之一。随着细菌的快速进化,常规抗生素的有效性正在减弱,这导致即使是最普通的感染也可能变得致命。这一现象已引起全球范围内的关注和行动紧急性。 了解抗生素抗药性 Antimicrobial resistance (who.int) 抗生素抗药性是指细菌对抗生素的改变,从而使抗生素变得无效。这种抗药性的细菌可能感染人类和动物,由它们引起的感染比非抗药性细菌引起的感染更难治疗。随着时间的推移,这种抗药性可以传播给其他细菌,形成一个更大的抗药性细菌群体。 抗药性机制  An overview of the antimicrobial resistance mechanisms of bacteria – PMC (nih.gov) 抗药性的形成通常是抗生素滥用和过度使用的直接后果。这包括在健康动物中大量使用抗生素以及为病毒感染(抗生素对此无效)开抗生素处方。每当人类使用抗生素时,敏感的细菌会被杀死,但可能会留下耐药的细菌繁殖和增加。反复和不当使用抗生素是导致细菌耐药性增加的主要原因之一。此外,环境中的抗生素残留也促使细菌进化出抗药性。 全球影响 据世界卫生组织(WHO)报道,抗生素抗药性导致医疗成本增加、住院时间延长及死亡率上升。这是一个全球性问题,越来越多的细菌感染,如结核病、沙门氏菌感染和肺炎,变得更难治疗。在某些地区,已经出现了几乎对所有已知抗生素均有抗药性的“超级细菌”。 Antimicrobial resistance (who.int) 应对抗生素抗药性的策略 结论 抗生素抗药性是一场需要全球协同合作的战斗。它不仅需要政府和卫生组织的介入,每个人都需参与其中,合理使用抗生素,以确保这一宝贵的医疗资源能够为未来的世代继续发挥效用。通过全球的共同努力,我们可以希望控制并最终克服这一危机。 The growing challenge of antibiotic resistance: A global health crisis Antibiotic resistance has emerged as one of the most formidable public health challenges of the 21st century. With bacteria evolving at an alarming rate, the efficacy of conventional antibiotics is diminishing, making even the most routine infections potentially deadly. This phenomenon has garnered global attention and calls for urgent action. Understanding antibiotic resistance Antibiotic resistance refers to changes in bacteria that render antibiotics ineffective. These resistant bacteria can infect both humans and animals, and the infections they cause are more difficult to treat than those caused by non-resistant bacteria. Over time, this resistance can spread to other bacteria, creating a larger population of resistant microbes. The mechanism behind resistance The emergence of resistance is primarily a direct consequence of antibiotic misuse and overuse. This includes extensive use of antibiotics in healthy animals and the prescription of antibiotics for viral infections (against which they are ineffective). Each time a person takes antibiotics, sensitive bacteria are killed, but resistant germs may be left to grow and multiply. Repeated and improper use of antibiotics is one of the primary causes of increased bacterial resistance. Additionally, antibiotic residues in the environment also encourage bacteria to evolve resistance. Global impact According to the World Health Organization, antibiotic resistance leads to higher medical costs, prolonged hospital stays, and increased mortality. It is a global problem that is becoming increasingly dangerous as many bacterial infections such as tuberculosis, salmonellosis, and pneumonia are becoming harder to treat. In some regions, “superbugs” that are nearly resistant to all known antibiotics have emerged. Strategies to combat antibiotic resistance Conclusion The battle against antibiotic resistance requires global cooperation. It demands involvement not just from governments and health organizations but from everyone. Proper antibiotic use is crucial to ensure that this valuable medical resource remains effective for future generations. Through collective global efforts, we can hope to control and ultimately overcome this crisis.

探索抗生素替代品:噬菌体疗法与抗菌肽的深入解析

By Tracy Chen, 3rd-year Pharmaceutical Science student at Monash University who completed her industry experience internship with us for the unit BPS3062. This is the first of several blog articles that Tracy has prepared, some in English and some in Mandarin. 随着抗生素抗药性的加剧,科学界正在探索更有效的替代治疗方法。噬菌体疗法和抗菌肽是两种显示出巨大潜力的替代策略,它们各自具有独特的作用机制和应用前景。 噬菌体疗法:精确打击特定细菌 噬菌体疗法利用特定的病毒——噬菌体,这些病毒专门感染和破坏细菌。每种噬菌体通常只针对一种或少数几种细菌,这种高度的专一性减少了对人体有益菌群的破坏,同时降低了细菌产生抗药性的风险。 抗菌肽:广谱的抗菌战士 Antimicrobial peptides: Source, application and recent developments – ScienceDirect 抗菌肽是一类短链氨基酸,具有强大的抗菌能力。它们能够迅速破坏多种细菌的细胞膜,包括一些耐抗生素的细菌。 Antimicrobial peptides: mechanism of action, activity and clinical potential – PMC (nih.gov) 结论 随着抗生素抗药性问题的加剧,噬菌体疗法和抗菌肽作为替代疗法显示出巨大的潜力和希望。这些策略通过各自独特的作用机制,为我们提供了对抗严峻细菌感染的新工具。持续的研究和技术发展将是推动这些替代疗法从实验室到临床应用的关键。

The rise of probiotics in animal agriculture

Decades of widespread antibiotic use in food production animals have given rise to a global problem with far-reaching implications for human health, animal welfare, and environmental sustainability. The practice of administering antibiotics to livestock and poultry was initially embraced for its perceived benefits in promoting growth and preventing diseases within crowded and often unsanitary conditions. However, the unintended consequences of this routine antibiotic use have triggered a multifaceted crisis. The overuse and misuse of antibiotics in food production has been a primary driver of antibiotic resistance, a global health crisis that jeopardises the effectiveness of these crucial drugs in treating bacterial infections. The constant exposure of bacteria to low levels of antibiotics in animal agriculture creates an environment where bacteria can develop resistance mechanisms. Resistant bacteria can then spread to humans through the consumption of contaminated food products, direct contact with animals, or exposure to contaminated environmental sources. The transmission of antibiotic-resistant bacteria from food animals to humans poses severe risks to public health. Resistant infections are more challenging to treat, often requiring stronger and more expensive antibiotics with increased potential for adverse side effects. In extreme cases, antibiotic-resistant infections can result in prolonged illnesses, increased mortality rates, and a higher burden on healthcare systems. The World Health Organization (WHO) has identified antibiotic resistance as a global threat that requires urgent attention and coordinated efforts across sectors. How to transform animal agriculture In recent years, a revolutionary shift has been occurring in animal agriculture as probiotics gain prominence as alternatives to traditional antibiotics. Fueled by concerns over antibiotic resistance, environmental impact, and consumer demand for sustainable practices, the use of probiotics is reshaping the landscape of livestock and poultry farming. This article explores the reasons behind this transformation, the benefits of probiotics, and the challenges and opportunities they present for animal agriculture. The antibiotic conundrum The overreliance on antibiotics in animal agriculture has raised substantial concerns about the development of antibiotic-resistant bacteria. This poses a significant threat to both animal and human health, as antibiotic-resistant infections become more challenging to treat. The use of antibiotics in livestock farming has also been linked to environmental issues. Antibiotics excreted by animals can enter water systems, contributing to the development of antibiotic-resistant strains in the environment and potentially impacting ecosystems. The emergence of Probiotics Probiotics are beneficial microorganisms, typically bacteria or yeast, that confer health benefits when consumed in adequate amounts. In animal agriculture, these microorganisms are used to promote a balanced gut microbiota, enhance digestion, and support overall animal health. Probiotics play a crucial role in maintaining a healthy gut microbiome in animals. A balanced gut microbiota is associated with improved nutrient absorption, enhanced immune function, and better overall performance. As a result, animals supplemented with probiotics often exhibit increased weight gain, improved feed conversion rates, and reduced susceptibility to diseases. Benefits of probiotics in animal agriculture Probiotics contribute to disease prevention by promoting a robust immune system and creating an environment in the gut that is less conducive to pathogenic bacteria. This reduces the need for antibiotics to treat and prevent diseases in animals. Probiotics enhance the efficiency of nutrient utilization in animals, leading to improved feed conversion rates. This not only benefits farmers economically but also aligns with sustainable farming practices by reducing the environmental impact associated with excessive feed use. One of the most significant advantages of probiotics in animal agriculture is their potential to replace or reduce the reliance on antibiotics. This shift aligns with global efforts to combat antibiotic resistance and addresses consumer preferences for products raised without the routine use of antibiotics. Challenges and opportunities Selecting effective probiotic strains and standardizing their use present challenges in the field. Research is ongoing to identify strains that provide consistent benefits across different animal species and production systems. The integration of probiotics into animal agriculture necessitates the development of clear regulatory frameworks. Establishing guidelines for probiotic use, quality control, and labeling ensures both efficacy and consumer confidence in these emerging practices. Farmers must be educated about the benefits and proper use of probiotics to encourage widespread adoption. Outreach programs, training initiatives, and collaborative efforts between researchers and the agricultural industry play a crucial role in facilitating this transition. Conclusion The transition from antibiotics to probiotics in animal agriculture marks a significant step toward sustainable and responsible farming practices. As concerns over antibiotic resistance and environmental impact intensify, probiotics offer a promising solution to enhance animal health, improve performance, and meet the growing demand for responsibly produced animal products. The ongoing research, regulatory developments, and educational initiatives surrounding probiotics in animal agriculture underscore a transformative journey that prioritises the well-being of animals, human health, and the environment.

Bacteriophage therapy and phage biocontrol

The antibiotic era largely put an end to bacteriophage therapy. Today, as a result of the global antibiotic resistance catastrophe, the world is turning to alternative ways to control bacteria … what better way than their natural enemies, bacteriophage.

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